Amber Degryse, MD

Amber Degryse, MDDr. Amber Degryse graduated first in her class from the University of South Florida College of Medicine and followed with a residency and fellowship in pulmonary and critical care medicine at Vanderbilt University Medical Center. She has dedicated many years to research in the area of lung repair with a focus on interstitial pulmonary fibrosis. Her research has been published in multiple top medical journals including The Proceedings of the National Academy of Sciences of the United States of America, American Journal of Respiratory and Critical Care Medicine, and the American Journal of Physiology, Lung Cellular and Molecular Physiology. Her research has been presented at national and international conferences. Dr. Degryse decided to leave academic research to pursue her true love, patient care. She is one of our interventional pulmonologists and is one of the few doctors in the area performing Endobronchial Ultrasound.

EDUCATION

Jacksonville University

B.S., summa cum laude
Jacksonville, Florida, 2000.

University of South Florida College of Medicine

M.D.
Tampa, Florida, 2004

Vanderbilt University

Residency-Internal Medicine
Nashville, Tennessee, 2006

Vanderbilt University

Fellowship- Pulmonary and Critical Care Medicine
Nashville, Tennessee 2011

BOARD CERTIFICATION and LICENSURE

Certification, Internal Medicine, 2007 - Present

Certification, Pulmonary Medicine, 2010 - Present

Certificiation, Critical Care Medicine, 2011 - Present

Medical License, State of Georgia, 2011 - Present

PRIOR GRANTS

IPF Net Career Development. Awarded 2010

1. To determine if telomere shortening in type II alveolar epithelial cells predisposes to the development of lung fibrosis by limiting this cell population's capacity to regenerate the alveolar epithelium following lung injury

2. To determine if interruption of the Beta-catenin signaling pathway results in aberrancies in type II alveolar epithelial cell plasticity, leading to inability to re-epithelialize areas of lung injury and subsequent fibrosis.

Ruth L. Kirschstein NRSA. Awarded 2008

1. To explain the association between heterozygous telomerase mutations and lung disease that has been noted in some cases of familial pulmonary fibrosis.

2. To determine if telomerase dysfunction and telomere length abnormalities play a role in disease pathogenesis even in the absence of a true telomerase mutation.

3. To utilize these studies to better understand the role of alveolar epithelium dysfunction in pulmonary fibrosis and shed light on the role that lung stem cell failure may play in disease pathogenesis.

HONORS AND AWARDS

Southern Society of Clinical Investigation Award for Best Scientific Abstract 2010

American Thoracic Society Travel Grant 2008

PUBLICATIONS

Degryse, AL, Tanjore H, Xu XC, Polosukhin VV, Jones BR, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE.

Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis. Am. J. Physiol. Lung Cell Mol. Epub ahead of print. Doi:10.1152/ajplung.00026.2010

Tanjore H, Xu XC, Polosukhin VV, Degryse AL, Li B, Han W, Sherrill TP, Plieth D, Neilson EG, Blackwell TS, Lawson WE

Contribution of epithelial derived fibroblasts to bleomycin induced lung fibrosis. Am. J. Respir. Crit. Care Med. 180(7):657-65, 2009.

Degryse A

A Wolf in Sheep's Clothing: Kaposi Sarcoma Mimicking a Bartholin's Gland Abscess. Southern Medical Journal. 2005; 98: 475-477.

Wills, Todd, Degryse, A., Lavina, J.

Blastoschizomyces capitus Pneumonia in an Immunocompetent Male. Southern Medical Journal. 2004; 97: 702-704

Degryse, A, Takagishi, J, Sinnott, J.

Group A streptococcus Septic Arthritis Mimicking Rheumatic Fever. Clinical Pediatrics. 2004; 43: 115-117.

Sinnott JT, Degryse A

Man vs Microbes. The Tampa Tribune, (Invited Editorial) March 29, 2003. (Picked up by USAToday, Yahoo, and BizWire)

Sinnott JT, Degryse A

Bookreview: Death and Dying. Journal of the American Medical Association. 2002; 289:235-236.

Sinnott JT, Degryse A

Emerging Threats. The Tampa Tribune, (Invited Editorial) September 29, 2002.

Degryse, Amber, Light, RW.

Pleural Effusion Monograph. BMJ Publishing Group, London, UK (in publication)

Book Chapters

Degryse A., Light, RW.

Pleural Effusions in Infectious Disease. Empiric Publishing (in production) 2009

Degryse A., Houston, S., Sinnott, J.

Dengue virus, in Olmstead RN(ed): Association for Professionals in Infection Control and Epidemiology (APIC) Infection Control and Applied Epidemiology Principles and Practice. St. Louis: Mosby-Year Book, Inc., Chapter 118 2003.

Abstracts

Degryse AL, Lawson WE, Phillips III JA, Armanios MY, Markin C, Blackwell TS, Loyd JE, Cogan JD.

Heterogeneous mutations in telomerase reverese transcriptase continue to be found in cases of familial interstitial pneumonia. Am. J. Respir. Crit. Care Med. 177:A887, 2008 (Abstract)

Degryse AL, Polosukhin VV, Blackwell TS, Lawson WE.

Repetitive bleomycin lung injury results in type II alveolar epithelial cell hyperplasia in areas of lung fibrosis. Am. J. Respir. Crit. Care Med. 179:A2720, 2009 (Abstract)

Xu XC, Tanjore H, Degryse AL, Polosukhin VV, Blackwell TS, Lawson WE.

Cell origin impacts phenotypic manifestations of lung fibroblasts. Am. J. Respir. Crit. Care Med. 179:A3433, 2009 (Abstract)

Tanjore H, Xu XC, Degryse AL, Blackwell TS, Lawson WE.

Epithelial-mesenchymal transition contributes to the FSP1 fibroblast population in bleomycin induced lung fibrosis. Am. J. Respir. Crit. Care Med. 179:A5389, 2009 (Abstract)

Degryse AL, Crossno PF, Tanjore H, Xu XC, Jones BR, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE.

Deletion of β-catenin in type II alveolar epithelial cells leads to enhanced lung injury and fibrosis following intratracheal bleomycin. Am. J. Respir. Crit. Care Med. 181:A1966, 2010 (Abstract)

Carrick RP, Degryse AL, Lawson WE, West JD, Haase VH, Blackwell TS.

Hypoxic signaling in bleomycin lung injury and pulmonary hypertension. Am. J. Respir. Crit. Care Med. 181:A1980, 2010 (Abstract)

Degryse AL, Cheng DS, Tanjore H, Polosukhin VV, Blackwell TS, Lawson WE.

Induction of endoplasmic reticulum stress exacerbates bleomycin induced lung fibrosis. Am. J. Respir. Crit. Care Med. 181:A2444, 2010 (Abstract)

Zoz DF, Crossno PF, Degryse AL, Markin CR, Polosukhin VV, Gleaves LA, Worrell JA, Johnson JE, Loyd LE, Lawson WE, Blackwell TS.

Evaluation of asymptomatic relatives of patients with familial interstitial pneumonia for evidence.

Tanjore H, Cheng DS, Degryse AL, Lawson WE, Blackwell TS.

Endoplasmic reticulum stress results in epithelial to mesenchymal transition in alveolar epithelial cells. Am. J. Respir. Crit. Care Med. 181:A1233, 2010 (Abstract)

Characteristic Lignin Signature of Aquatic Humic Substances

Abstract for Presentation. National Undergraduate Research Symposium. Maryland 1998

Characteristic Lignin Signature of Aquatic Humic Substances

Abstract for Presentation. National Undergraduate Research Symposium. Rochester, NY 1999

Presentations

Deletion of β-catenin in type II alveolar epithelial cells leads to enhanced lung injury and fibrosis following intratracheal bleomycin

FASEB, Saxton's River, VT 2010

Epithelial Cell in Injury, Repair, and Fibrosis

Medicine Grand Rounds, Jan 2010

Induction of endoplasmic reticulum stress exacerbates bleomycin induced lung fibrosis

ATS Conference, LA. May 2010

Deletion of β-catenin in type II alveolar epithelial cells leads to enhanced lung injury and fibrosis following intratracheal bleomycin

ATS Conference, New Orlean, LA. May 2010

The Epithelial Cell: Key to Pulmonary Fibrosis

Harrison Society Research Lecture Dinner, November 2009

How to Run a Code

Medical Student lecture series, Vanderbilt University Medical School. March 2009

Repetitive Bleomycin Lung Injury Leads to Prominence of Type II Alveolar Epithelial Cell Hyperplasia

ATS Conference. San Diego, CA May 2009

Repetitive Bleomycin Lung Injury Leads to Prominence of Type II Alveolar Epithelial Cell Hyperplasia

FASEB Conference, Saxtons River, VT June 2008

Telomerase and Epithelial Cell Dysfunction in IPF

Pulmonary Grand Rounds, Division of Allergy, Pulmonary, and Critical Care. March 2008

Modes of Mechanical Ventilation

Med-Peds lunch lecture series, April 2008

Respiratory Disease in the Immunocompromised Host

Pulmonary Fellows Lecture Series, Division of Allergy, Pulmonary, and Critical Care. August 2008

The Characteristic Lignin Signature of Aquatic Humic Substances

Undergraduate Research Symposium, Jacksonville University. 1998- 2000

The Characteristic Lignin Signature of Aquatic Humic Substances

National Conference for Undergraduate Research, University of Rochester, Rochester, New York, 1999

The Characteristic Lignin Signature of Aquatic Humic Substances

National Conference for Undergraduate Research, Salisbury State University, Salisbury, Maryland, 1998

COMMITTEES

CAUTI, 2011 - present

Clinical Documentation Improvement, 2014

ICD-10 implementation, 2014

Venothromboembolism Prevention, 2012 - present

Smoking Cessation Committee, 2013 - present

Interventional Bronchoscopy Oversight, 2011-present

Critical Care Committee, 2011 - present

SOCIETY MEMBERSHIP

Member, American Thoracic Society 2008-present

Member, Tennessee Medical Association 2004-present

Member, American Medical Association 2000- present

Member, Florida Medical Association 2000-present

Member, American Medical Student Association 2000-present